Angiogenesis and Fibrogenesis in Chronic Liver Diseases
نویسندگان
چکیده
منابع مشابه
Angiogenesis and Fibrogenesis in Chronic Liver Diseases
Pathologic angiogenesis appears to be intrinsically associated with the fibrogenic progression of chronic liver diseases, which eventually leads to the development of cirrhosis and related complications, including hepatocellular carcinoma. Several laboratories have suggested that this association is relevant for chronic liver disease progression, with angiogenesis proposed to sustain fibrogenes...
متن کاملHypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases.
Angiogenesis is a dynamic, hypoxia-stimulated and growth factor-dependent process, and is currently referred to as the formation of new vessels from pre-existing blood vessels. Experimental and clinical studies have unequivocally reported that hepatic angiogenesis, irrespective of aetiology, occurs in conditions of chronic liver diseases (CLDs) characterized by perpetuation of cell injury and d...
متن کاملHypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.
Fibrogenic progression of chronic liver diseases (CLDs) towards the end-point of cirrhosis is currently regarded, whatever the aetiology, as a dynamic and highly integrated cellular response to chronic liver injury. Liver fibrogenesis (i.e., the process) is sustained by hepatic populations of highly proliferative, pro-fibrogenic and contractile myofibroblast-like cells (MFs) that mainly origina...
متن کاملSerum markers of liver fibrogenesis, and liver histology findings in patients with chronic liver diseases.
AIM OF THE STUDY Investigation of the relationships between the grade and stage of chronic liver diseases irrespective of their etiology using some novel serum markers of liver fibrogenesis, the "classical" serum markers of liver necro-inflammatory injury (such as transaminases), and the histomorphological evaluation of liver biopsies. METHODS Markers of liver fibrogenesis: serum metalloprote...
متن کاملAngiogenesis in chronic liver disease.
BACKGROUND Chronic liver disease is characterized by inflammation and fibrosis. As a consequence angiogenesis leading to new vasculature may have prognostic value in disease progression. Interfering with angiogenesis may be a potential target to avoid progression of liver disease. Hence we planned to evaluate the CD34 and vascular endothelial growth factor (VEGF), the markers for angiogenesis i...
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ژورنال
عنوان ژورنال: Cellular and Molecular Gastroenterology and Hepatology
سال: 2015
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2015.06.011